Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms
Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Morgan CJ, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP
PLoS Biol. 2024;22: e3002205.
highlighted by Andrea Du Toit in Nature Reviews Microbiology
MpaR-driven expression of an orphan terminal oxidase subunit supports Pseudomonas aeruginosa biofilm respiration and development during cyanogenesis
Smiley MK, Sekaran DC, Forouhar F, Wolin E, Jovanovic M, Price-Whelan A, Dietrich LE (2024)
mBio. 15: e0292623.
Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylation
Evans CR, Smiley MK, Thio SA, Wei M, Price-Whelan A, Min W, Dietrich LE (2023)
Proc Natl Acad Sci U S A. 120(43):e2313208120
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa
Scribani Rossi C, Eckartt K, Scarchilli E, Angeli S, Price-Whelan A, Di Matteo A, Chevreuil M, Raynal B, Arcovito A, Giacon N, Fiorentino F, Rotili D, Mai A, Espinosa-Urgel M, Cutruzzolà F, Dietrich LEP, Paone A, Paiardini A, Rinaldo S.
Microbiol Res. 2023 Dec 1;277:127498
Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples
Chen Y, Chauhan S, Gong C, Dayton H, Xu C, De La Cruz ED, Datta MS, Leong KW, Dietrich LEP, Tomer R (2023)
bioRxiv 2023.05.31.543173
Cell arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms
Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP (2023)
bioRxiv 2023.06.20.545666. doi:10.1101/2023.06.20.545666
Cyanide-dependent control of terminal oxidase hybridization by Pseudomonas aeruginosa MpaR
Smiley MK, Sekaran DC, Price-Whelan A, Dietrich LEP (2023)
bioRxiv p. 2023.05.31.543164. doi:10.1101/2023.05.31.543164
Charge mapping of Pseudomonas aeruginosa using a Hopping Mode Scanning Ion Conductance Microscopy technique
Rabinowitz J, Hartel Andreas, Dayton H, Fabbri J, Jo J, Dietrich L, Shepard K (2023)
Rabinowitz J, Hartel Andreas, Dayton H, Fabbri J, Jo J, Dietrich L, Shepard K (2023)
Analytical Chemistry 5(12):5285–5292
Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylation
Evans CR, Smiley MK, Thio SA, Wei M, Price-Whelan A, Min W, Dietrich LE (2023)
bioRxiv 2023.02.15.528762. doi:10.1101/2023.02.15.528762
Light/Dark and temperature cycling modulate metabolic electron flow in Pseudomonas aeruginosa biofilms
Kahl LJ, Eckartt KN, Morales DK., Price-Whelan A, Dietrich LEP (2022)
MBio 0:e01407–22.
Gradients and consequences of heterogeneity in biofilms
Jo J, Price-Whelan A, Dietrich, LEP (2022)
Nature Reviews Microbiology, 1–15.
Light/dark and temperature cycling modulate metabolic electron flow in Pseudomonas aeruginosa biofilms
Kahl LJ, Eckartt K, Morales DK, Price-Whelan A, & Dietrich LEP (2022)
bioRxiv 2022.02.07.479496; https://doi.org/10.1101/2022.02.07.479496
Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies
Díaz-Pascual F, Lempp M, Nosho K, Jeckel H, Jo JK, Neuhaus K, Hartmann R, Jelli E, Hansen MF, Price-Whelan A, Dietrich LE, Link H, & Drescher K (2021)
eLife, 10. https://doi.org/10.7554/eLife.70794
Sensory perception in bacterial cyclic diguanylate signal transduction
Randall TE, Eckartt K, Kakumanu S. Price-Whelan A, Dietrich LEP, & Harrison, JJ (2021)
Journal of Bacteriology, JB0043321.
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions
O’Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F et al. (2021)
MBio 0, e01763–21
Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence
Wang B, Lin YC, Vasquez-Rifo A, Jo J, Price-Whelan A, McDonald ST, Brown LM, Sieben C, Dietrich LEP (2021)
Nature Communications 12: 4613
Alanine cross-feeding determines Escherichia coli colony growth dynamics
Díaz-Pascual F, Lempp M, Nosho K, Jeckel H, Jo JK, Neuhaus K, Hartmann R, Jelli E, Hansen MF, Dietrich, LEP, Link H, Drescher, K (2021)
bioRxiv 2021.02.28.433255; https://doi.org/10.1101/2021.02.28.433255
Redox cycling-based detection of phenazine metabolites secreted from Pseudomonas aeruginosa in nanopore electrode arrays
Do H, Kwon S, Baek S, Madukoma CS, Smiley MK, Dietrich LE, Shrout J, Bohn PW (2021)
Analyst, DOI: 10.1039/D0AN02022B
Pseudomonas aeruginosa PA14 biofilms produce R-bodies, extendable protein polymers with roles in host colonization and virulence
Wang B, Lin YC, Jo J, Price-Whelan A, McDonald ST, Brown LM, Dietrich LEP (2020)
bioRxiv 2020.10.26.356394; https://doi.org/10.1101/2020.10.26.356394
Mid-infrared metabolic imaging with vibrational probes
Shi L, Liu X, Shi L, Stinson HT, Rowlette J, Kahl LJ, Evans CR, Zheng C, Dietrich LEP, Min W (2020)
Nature Methods, 17(8), 844–851
Metabolic Heterogeneity and Cross-Feeding in Bacterial Multicellular Systems
Evans CR, Kempes CP, Price-Whelan A, Dietrich LEP (2020)
Trends in Microbiology, 28(9):732–743.
Phenazine oxidation by a distal electrode modulates biofilm morphogenesis
Cornell WC, Zhang Y, Bendebury A, Hartel AJW, Shepard KL, & Dietrich, LEP (2020)
Biofilm, 100025.
Light-mediated decreases in cyclic di-GMP levels inhibit structure formation in Pseudomonas aeruginosa biofilms
Kahl, LJ, Price-Whelan, A, & Dietrich, LEP (2020).
Journal of Bacteriology 202 (14)
Pseudomonas 2019 meeting report
Hardie KR, Mathee K, Schweizer HP, Dietrich LE, Welch M, de Kievit T, Nguyen D, Kivisaar M, Dandekar AA, McDougald D, & Winstanley C (2020)
Journal of Medical Microbiology. https://doi.org/10.1099/jmm.0.001208
Evaluation of data analysis platforms and compatibility with MALDI-TOF imaging mass spectrometry data sets
Luu GT, Condren AR, Kahl LJ, Dietrich LEP, Sanchez LM (2020)
Journal of the American Society for Mass Spectrometry
Interdependency of respiratory metabolism and phenazine-associated physiology in Pseudomonas aeruginosa PA14
Jo J, Price-Whelan A, Cornell WC, Dietrich LEP (2020)
Journal of Bacteriology 202 (4)
Sensory Domains That Control Cyclic di-GMP-Modulating Proteins: A Critical Frontier in Bacterial Signal Transduction
Dayton H, Smiley MK, Forouhar F, Harrison JJ, Price-Whelan A, Dietrich, LEP (2020)
In S.-H. Chou, N. Guiliani, V. T. Lee, & U. Römling (Eds.), Microbial Cyclic Di-Nucleotide Signaling (pp. 137–158). Springer International Publishing.
Biofilm inhibitor taurolithocholic acid alters colony morphology, specialized metabolism, and virulence of Pseudomonas aeruginosa
Condren AR, Kahl LJ, Boelter G, Kritikos G, Banzhaf M, Dietrich LEP, Sanchez LM (2020)
ACS Infectious Diseases
Phenazine Production Promotes Antibiotic Tolerance and Metabolic Heterogeneity in Pseudomonas aeruginosa biofilms
Schiessl KT, Hu F, Jo J, Nazia SZ, Wang B, Price-Whelan A, Min W, and Dietrich LEP (2019)
Nature Communications 10 (1): 762.
The Pseudomonas aeruginosa complement of lactate dehydrogenases enables use of D- and L-lactate and metabolic crossfeeding
Lin YC, Cornell WC, Price-Whelan A, Dietrich LEP (2018)
MBio (9) doi:10.1128/mBio.00961-18
Paraffin embedding and thin sectioning of microbial colony biofilms for microscopic analysis
Cornell WC, Morgan CJ, Koyama L, Sakhtah H, Mansfield JH, Dietrich LEP (2018)
Journal of Visualized Experiments (133)
The phenazine utilizing monooxygenase PumA affects biofilm physiology in Pseudomonas aeruginosa
Sporer A, Beierschmitt A, Bendebury A, Zink K, Price-Whelan ABuzzeo MC, Sanchez L, Dietrich LEP (2018)
Microbiology 164(5), 790–800
Phenazines regulate Nap-dependent denitrification in Pseudomonas aeruginosa biofilms
Lin YC, Sekedat MD, Cornell WC, Silva GM, Okegbe C, Price-Whelan A, Vogel C and Dietrich LEP (2018)
Journal of Bacteriology 200(9), e00031-18
An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence
Jo J, Cortez KL, Cornell WC, Price-Whelan A, Dietrich LE (2017)
eLife 6:e30205
Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms
Fong JCN, Rogers A, Michael AK, Parsley NC, Cornell WC, Lin YC, Singh PK, Hartmann R, Drescher K, Vinogradov E, Dietrich LEP, Partch CL, Yildiz FH (2017)
eLife 6:e26163
Redox-based regulation of bacterial development and behavior
Sporer A, Kahl L, Price-Whelan A, Dietrich LEP (2017)
Annual Review of Biochemistry 86:777-797
Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP
Okegbe C, Fields BL, Cole SJ, Beierschmitt C, Morgan CJ, Price-Whelan A, Stewart RC, Lee VT, Dietrich LEP (2017)
Proceedings of the National Academy of Sciences of the United States of America 114(26)
Bifunctionality of a biofilm matrix protein controlled by redox state
Arnaouteli S, Ferreira AS, Schor M, Morris RJ, Bromley KM, Jo J, Cortez KL, Sukhodub T, Prescott AR, Dietrich LEP, MacPhee CE, Stanley-Wall NR (2017)
Proceedings of the National Academy of Sciences of the United States of America 114(30)
Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer
Maderbocus R, Fields BL, Hamilton K, Luo S, Tran T, Dietrich LE, Tong L (2017)
Nature Communications 8: 160
A distinct holoenzyme organization for two-subunit pyruvate carboxylase
Choi PH, Jo J, Lin YC, Lin MH, Chou CY, Dietrich LE, Tong L (2016)
Nature Communications 7:12713
The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development
Sakhtah H, Koyama L, Zhang Y, Morales DK, Fields BL, Price-Whelan A, Hogan DA, Shepard K, Dietrich LEP (2016)
Proceedings of the National Academy of Sciences of the United States of America 113(25), E3538–E3547
Electrochemical camera chip for simultaneous Imaging of multiple metabolites in biofilms
Bellin DL, Sakhtah H, Zhang Y, Price-Whelan A, Dietrich LEP*, Shepard KL* (2016)
Nature Communications 7:10535
* corresponding authors
Facultative control of matrix production optimizes competitive fitness in Pseudomonas aeruginosa PA14 biofilm models
Madsen JS, Lin YC, Squyres GR, Price-Whelan A, de Santiago Torio A, Song A, Cornell WC, Sørensen SJ, Xavier JB, Dietrich LEP (2015)
Appl Environ Microbiol. 81(24), 8414-26
highlighted in AEM Spotlight
Motility, chemotaxis and aerotaxis contribute to competitiveness during bacterial pellicle biofilm development
Holscher, T., Bartels, B., Lin, Y. C., Gallegos-Monterrosa, R., Price-Whelan, A., Kolter, R., Dietrich LEP, Kovacs, A. T. (2015) Journal of Molecular Biology. doi: 10.1016/j.jmb.2015.06.014
recommended in Faculty of 1000
Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase
Tran TH, Hsiao Y-S, Jo J, Chou, C-Y, Dietrich LEP, Walz T, & Tong L (2015)
Nature 518(7537), 120–124
Candida albicans Ethanol Stimulates Pseudomonas aeruginosa WspR-Controlled Biofilm Formation as Part of a Cyclic Relationship Involving Phenazines
Chen AI, Dolben EF, Okegbe C, Harty, Golub Y, Thao S, Ha DG, Willger SD, O'Toole GA, Harwood CS, LEP Dietrich, DA Hogan (2014)
PLoS Pathogens 10(10):e1004480
An Aerobic Exercise: Defining the Roles of Pseudomonas aeruginosa Terminal Oxidases
Jo J, Price-Whelan A, Dietrich LEP (2014)
Journal of Bacteriology 196(24):4203-4205
Redox-driven regulation of microbial community morphogenesis
Okegbe C, Price-Whelan A, Dietrich LEP (2014)
Current Opinion in Microbiology 18: 39–45
Integrated circuit-based electrochemical sensor for spatially resolved detection of redox-active metabolites in biofilms
Bellin DL, Sakhtah H, Rosenstein JK, Levine PM, Thimot J, Emmett K, Dietrich LEP*, Shepard KL* (2014)
Nature Communications 5:3256
* corresponding authors
highlighted in Columbia University News, ASM Microbe , Xinhua News
Morphological optimization for access to dual oxidants in biofilms
Kempes C, Okegbe C, Mears-Clarke Z, Follows M, Dietrich LEP (2014)
Proceedings of the National Academy of Sciences of the United States of America 111(1):208-13
highlighted in MIT news
Regulation of phenazine biosynthesis
Sakhtah H, Price-Whelan A, Dietrich LEP (2014)
in Microbial Phenazines: Biosynthesis, Agriculture and Health (Springer)
Convergent evolution of hyperswarming leads to impaired biofilm formation in pathogenic bacteria
van Ditmarsch D, Boyle KE, Sakhtah H, Oyler JE, Nadell CD, Deziel E, Dietrich LEP, Xavier JB (2013)
Cell Reports 4(4): 697-708
highlighted in NY Times
Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines
Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA. (2013)
MBio 4(1):e00526-12
Bacterial community morphogenesis is intimately linked to the intracellular redox state
Dietrich LEP*, Okegbe C, Price-Whelan A, Sakhtah H, Hunter RC, Newman DK (2013)
Journal of Bacteriology 195(7):1371-80
* corresponding author
highlighted in Nature Reviews Microbiology
Species-specific residues calibrate SoxR sensitivity to redox-active molecules
Sheplock R, Recinos DA, Mackow N, Dietrich LE*, Chander M* (2013)
Molecular Microbiology 87(2):368-81
* corresponding authors
Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity
Recinos DA, Sekedat MD, Hernandez A, Cohen TS, Sakhtah H, Prince AS, Price-Whelan A, Dietrich LE (2012)
Proceedings of the National Academy of Sciences of the United States of America 109(47):19420-5
recommended in Faculty of 1000
The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LEP, Bruscia EM (2012)
PLoS ONE 7, e35499 (2012)
Redox Eustress: Roles for Redox-Active Metabolites in Bacterial Signaling and Behavior
Okegbe C, Sakhtah H, Sekedat M, Price-Whelan A, Dietrich LEP (2012)
Antioxidants & Redox Signaling, 16(7):658-67
Biological control of Rhizoctonia root rot on bean by phenazine and cyclic lipopeptide producing Pseudomonas CMR12a
D'aes J, Hua GK, De Maeyer K, Pannecoucque J, Forrez I, Ongena M, Dietrich LE, Thomashow LS, Mavrodi D, Höfte M (2011)
Phytopathology 101(8):996-1004
A shared mechanism of SoxR activation by redox-cycling compounds
Dietrich LE, Kiley PJ (2011)
Molecular Microbiology 79 (5), 1119-1122
Phenazines affect biofilm formation by Pseudomonas aeruginosa in similar ways at various scales
Ramos I*, Dietrich LE*, Price-Whelan A, Newman DK (2010)
Research in Microbiology 161:187-191
(* contributed equally)
Redox-active antibiotics control gene expression and community behavior in divergent bacteria
Dietrich LE, Teal TK, Price-Whelan A, Newman DK (2008)
Science 321(5893):1203-6;
highlighted in C&E News
DNA Binding shifts the Redox Potential of the Transcription Factor SoxR
Gorodetsky A*, Dietrich LE*, Lee P, Newman DK, Barton JK (2008)
Proceedings of the National Academy of Sciences of the United States of America 105: 3684-9
(* contributed equally)
Recommended in Faculty of 1000
Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14
Price-Whelan A, Dietrich LE, Newman DK (2007)
Journal of Bacteriology 189: 6372-6381
The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa
Dietrich LE, Price-Whelan A, Petersen A, Whiteley M, Newman DK (2006)
Molecular Microbiology 61: 1308-1321
Recommended in Faculty of 1000
The co-evolution of life and Earth
Dietrich LE, Tice MM, Newman DK (2006)
Current Biology 16: R395-400
Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics
Price-Whelan A, Dietrich LE, Newman DK (2006)
Nature Chemical Biology 2: 71-78
Palmitoylation determines the function of Vac8 at the yeast vacuole
Subramanian K*, Dietrich LE*, Hou H, LaGrassa TJ, Meiringer CT, Ungermann C (2006)
Journal of Cell Science 119: 2477-2485 (* contributed equally)
The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion
Dietrich LE, Peplowska K, LaGrassa TJ, Hou H, Rohde J, Ungermann C (2005)
EMBO Reports 6: 245-250
The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.
Hou H, Subramanian K, LaGrassa TJ, Markgraf D, Dietrich LE, Urban J, Decker N, Ungermann C (2005)
Proceedings of the National Academy of Sciences of the United States of America 102: 17366-17371
ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles
Dietrich LE, LaGrassa TJ, Rohde J, Cristodero M, Meiringer CT, Ungermann C (2005)
The Journal of Biological Chemistry 280: 15348-15355
On the mechanism of protein palmitoylation
Dietrich LE, Ungermann C (2004)
EMBO Reports 5: 1053-1057
Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators
Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F (2004)
Trends in Biochemical Sciences 29: 682-688
The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion
Dietrich LE, Gurezka R, Veit M, Ungermann C (2004)
The EMBO Journal 23: 45-53
Recommended in Faculty of 1000
Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
Dietrich LE, Boeddinghaus C, LaGrassa TJ, Ungermann C (2003)
Biochimica et Biophysica Acta 1641: 111-119
Biochemical characterization of the vacuolar palmitoyl acyltransferase
Veit M, Dietrich LE, Ungermann C (2003)
FEBS letters 540: 101-105
The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion
Rohde J, Dietrich L, Langosch D, Ungermann C (2003)
The Journal of Biological Chemistry 278: 1656-1662
Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion
Veit M, Laage R, Dietrich L, Wang L, Ungermann C (2001)
The EMBO Journal 20: 3145-3155
Structural consequences of cyclophilinA binding on maturational refolding in human immunodeficiency virus type 1 capsid protein
Dietrich L, Ehrlich LS, LaGrassa TJ, Ebbets-Reed D, Carter C (2001)
Journal of Virology 75: 4721-4733